On Windows 10 with a Solid State Drive (SSD) I started to notice issues with my computer locking up for seconds (possibly minutes) and then freeing up. So when it would lock up you would click around and nothing would happen and when it unlocks or frees up, all the actions would finally catch up on the machine. Of course this drove me nuts.
Eventually I narrowed the issue down to Google Chrome and this message in the status bar “Waiting for Cache” message. To confirm, I basically lived on Firefox for a few days and this helped me narrow down the fact that something was up in Chrome (I had uninstalled Chrome completely).
I gave Chrome another try by re-installing it. I noticed the same issues reoccurring. I tinkered with many settings in Google Chrome (v52 if you are interested) and was able to increase Google Chrome’s performance by removing the Hardware Acceleration setting and the Continue running background apps..(Advanved Settings, System section). I also cleared cache ( removing everything and using the Since the Beginning of time option ). Since I have made these changes my system is running better.
Hope this helps.